Guangcun Huang
State/Province:
OH
Country:
United States
Current Affiliation:
The Research Institute at Nationwide Children's Hospital
Current Position:
Research Fellow
Career Highlights:
My main research interests are molecular mechanisms in the development of liver fibrosis and prevention/therapeutic intervention of liver fibrosis, and I have had several papers published in international peer-reviewed journals.
In January 2008, I joined a premier connective tissue growth factor (CTGF, also known as CCN2) research lab, to study the molecular mechanisms of CTGF in hepatic stellate cells (HSC) function and in the development of liver diseases and fibrotic diseases in other organs such as pancreas.
I’ve been invited and have been serving as a referee for five international journals, including Gut, Liver International, Journal of Gastroenterology and Hepatology, and Acta Pharmacologica Sinica. Since 2005 I also served as an editorial board member of World Journal of Gastroenterology, and recently was invited to be editorial board member of World Journal of Hepatology.
In January 2008, I joined a premier connective tissue growth factor (CTGF, also known as CCN2) research lab, to study the molecular mechanisms of CTGF in hepatic stellate cells (HSC) function and in the development of liver diseases and fibrotic diseases in other organs such as pancreas.
I’ve been invited and have been serving as a referee for five international journals, including Gut, Liver International, Journal of Gastroenterology and Hepatology, and Acta Pharmacologica Sinica. Since 2005 I also served as an editorial board member of World Journal of Gastroenterology, and recently was invited to be editorial board member of World Journal of Hepatology.
Field of Research:
MEDICAL AND HEALTH SCIENCES - Clinical Sciences - Gastroenterology and Hepatology
Professional Memberships:
Regular Membership of American Association for the Study of Liver Diseases (AASLD);
Membership of American Association for the Advancement of Science (AAAS);
Regular Membership (Gold) of International Society for Hepatic Sinusoidal Research (ISHSR).
Membership of American Association for the Advancement of Science (AAAS);
Regular Membership (Gold) of International Society for Hepatic Sinusoidal Research (ISHSR).
Research Interests:
Fibrotic Diseases, including Liver and Pancreatic Fibrosis/Cirrhosis.
Publication History:
SELECTED PUBLICATIONS:
•Peer-reviewed Journals:
1. James IAO, Chen CL, Huang G, Zhang HY, Velten M, Besner GE. HB-EGF Protects the Lungs after Intestinal Ischemia/Reperfusion Injury. J Surg Res (in press)
2. Huang G, Brigstock DR. Integrin expression and function in the response of primary culture hepatic stellate cells to Connective Tissue Growth Factor (CCN2).J Cell Mol Med (in press) (PMID: 20406330)
3. Lawrencia C, Charrier A, Huang G, Brigstock DR. Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells. Growth Factors 27:91-99 (2009) (PMID: 19280452)
4. Wang X, Huang G, Mei S, Qian J, Ji J, Zhang J. Over-expression of C/EBP-α induces apoptosis in cultured rat hepatic stellate cells depending on p53 and peroxisome proliferator-activated receptor-γ. Biochem Biophys Res Commun 380:286-291 (2009) (PMID:19168033)
5. Ji J, Zhang J, Huang G, Qian J, Wang X, Mei S. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583:759-766 (2009) (PMID: 19185571)
6. Gu J, Zhuang L, Huang GC*. Melatonin prevents H2O2-induced activation of rat hepatic stellate cells. J Pineal Res 41:275-278 (2006) (PMID: 16948789)
7. Li W, Zhang J, Huang G, Zhu H, Zhang X. Long-term administering low anticoagulant activity heparin can lessen rat hepatic fibrosis induced by either CCl4 or porcine serum injection. Hepatol Res 36:115-123 (2006) (PMID: 16904936) (Erratum in: Hepatol Res 2008;38:114)
8. Wang Y, Zhang JS, Qian J, Huang GC, Chen Q. Adrenomedullin regulates expressions of transforming growth factor-β1 and β1-induced matrix metalloproteinase-2 in hepatic stellate cells. Int J Exp Pathol 87:177-184 (2006) (PMID: 16709226)
9. Wang Y, Zhang JS, Huang GC, Cheng Q, Zhao ZH. Effects of adrenomedullin gene overexpression on biological behavior of hepatic stellate cells. World J Gastroenterol 11:3549-3553 (2005) (PMID: 15962372)
10. Chen C, Zhang J, Li J, Huang J, Yang C, Huang G, Shi J. Hydrodynamic-based in vivo transfection of retinoic X receptor-alpha gene can enhance vitamin A-induced attenuation of liver fibrosis in mice. Liver Int 24:679-686 (2004) (PMID: 15566521)
11. Huang GC, Zhang JS, Tang QQ. Involvement of C/EBP-α gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun 324:1309-1318 (2004) (PMID: 15504357)
12. Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang XR. Effect of RARβ transfection on the proliferation and phenotype of rat hepatic stellate cells. Chin J Hepatol 10:297-300 (2002) (PMID: 12223147) (in Chinese)
13. Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang XR. Effect of retinoid X receptor alpha (RXRα) transfection on the proliferation and phenotype of rat hepatic stellate cells in vitro. Chin Med J 115:928-932 (2002) (PMID: 12123568)
14. Huang GC*, Zhang JS, Zhang YE. Effects of retinoic acid on proliferation, phenotype and expression of cyclin-dependent kinase inhibitors in TGF-β1-stimulated rat hepatic stellate cells. World J Gastroenterol 6:819-823 (2000) (PMID: 11819702)
15. Li WC, Zhang JS, Huang GC, Zhu HG, Zhang XR, Zhang YE. Effects of heparin on the growth, extracellular matrix and matrix metalloproteinase gene expression in rat hepatic stellate cells. Chin J Hepatol 8:200-202 (2000) (PMID: 10951616) (in Chinese)
16. Chen YJ, Zhao ZQ, Gu YJ, Huang GC. Immunohistochemical study on myoglobin in electrocution. J Forensic Med 13: 12-13,64 (1997) (PMID: 9644151) (in Chinese)
•Reviews:
1. Huang GC, Zhang JS. CCAAT/enhancer-binding protein family and liver diseases. Chin J Hepatol 11(1):57-59 (2003) (PMID: 12546754) (in Chinese)
•Meeting Abstracts:
1. Huang G, Brigstock DR. Differential modulation of integrins gene expression by connective tissue growth factor in early and activated primary culture hepatic stellate cells. Digestive Disease Week (DDW) 2009, May 30-June 4, Chicago, IL, USA. Meeting abstract published in Gastroenterology 136(Suppl):A-822 (2009)
2. Huang G, Brigstock DR. Integrin α5β1 is a CTGF receptor on early primary culture hepatic stellate cells and interacts with fibronectin and heparan sulfate proteglycans to regulate CTGF function. Digestive Disease Week (DDW) 2009, May 30-June 4, Chicago, IL, USA. Meeting abstract published in Gastroenterology 136(Suppl):A-823 (2009)
3. Huang GC*. Expression of c-maf gene in hepatic stellate cells. Digestive Disease Week (DDW) 2006, May 20-27, Los Angeles, CA, USA. Meeting abstract published in Gastroenterology 130(Suppl2):A796 (2006)
4. Huang GC, Tang QQ, Zhang JS. All-trans retinoic acid suppresses TGF-1-induced activation of rat hepatic stellate cells. The 95th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Feb 11-17, Atlanta, GA, USA. Meeting Abstract Published in Lab Invest 19(Suppl):273A (2006).
http://www.researcherid.com/rid/B-8399-2008
•Peer-reviewed Journals:
1. James IAO, Chen CL, Huang G, Zhang HY, Velten M, Besner GE. HB-EGF Protects the Lungs after Intestinal Ischemia/Reperfusion Injury. J Surg Res (in press)
2. Huang G, Brigstock DR. Integrin expression and function in the response of primary culture hepatic stellate cells to Connective Tissue Growth Factor (CCN2).J Cell Mol Med (in press) (PMID: 20406330)
3. Lawrencia C, Charrier A, Huang G, Brigstock DR. Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells. Growth Factors 27:91-99 (2009) (PMID: 19280452)
4. Wang X, Huang G, Mei S, Qian J, Ji J, Zhang J. Over-expression of C/EBP-α induces apoptosis in cultured rat hepatic stellate cells depending on p53 and peroxisome proliferator-activated receptor-γ. Biochem Biophys Res Commun 380:286-291 (2009) (PMID:19168033)
5. Ji J, Zhang J, Huang G, Qian J, Wang X, Mei S. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583:759-766 (2009) (PMID: 19185571)
6. Gu J, Zhuang L, Huang GC*. Melatonin prevents H2O2-induced activation of rat hepatic stellate cells. J Pineal Res 41:275-278 (2006) (PMID: 16948789)
7. Li W, Zhang J, Huang G, Zhu H, Zhang X. Long-term administering low anticoagulant activity heparin can lessen rat hepatic fibrosis induced by either CCl4 or porcine serum injection. Hepatol Res 36:115-123 (2006) (PMID: 16904936) (Erratum in: Hepatol Res 2008;38:114)
8. Wang Y, Zhang JS, Qian J, Huang GC, Chen Q. Adrenomedullin regulates expressions of transforming growth factor-β1 and β1-induced matrix metalloproteinase-2 in hepatic stellate cells. Int J Exp Pathol 87:177-184 (2006) (PMID: 16709226)
9. Wang Y, Zhang JS, Huang GC, Cheng Q, Zhao ZH. Effects of adrenomedullin gene overexpression on biological behavior of hepatic stellate cells. World J Gastroenterol 11:3549-3553 (2005) (PMID: 15962372)
10. Chen C, Zhang J, Li J, Huang J, Yang C, Huang G, Shi J. Hydrodynamic-based in vivo transfection of retinoic X receptor-alpha gene can enhance vitamin A-induced attenuation of liver fibrosis in mice. Liver Int 24:679-686 (2004) (PMID: 15566521)
11. Huang GC, Zhang JS, Tang QQ. Involvement of C/EBP-α gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun 324:1309-1318 (2004) (PMID: 15504357)
12. Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang XR. Effect of RARβ transfection on the proliferation and phenotype of rat hepatic stellate cells. Chin J Hepatol 10:297-300 (2002) (PMID: 12223147) (in Chinese)
13. Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang XR. Effect of retinoid X receptor alpha (RXRα) transfection on the proliferation and phenotype of rat hepatic stellate cells in vitro. Chin Med J 115:928-932 (2002) (PMID: 12123568)
14. Huang GC*, Zhang JS, Zhang YE. Effects of retinoic acid on proliferation, phenotype and expression of cyclin-dependent kinase inhibitors in TGF-β1-stimulated rat hepatic stellate cells. World J Gastroenterol 6:819-823 (2000) (PMID: 11819702)
15. Li WC, Zhang JS, Huang GC, Zhu HG, Zhang XR, Zhang YE. Effects of heparin on the growth, extracellular matrix and matrix metalloproteinase gene expression in rat hepatic stellate cells. Chin J Hepatol 8:200-202 (2000) (PMID: 10951616) (in Chinese)
16. Chen YJ, Zhao ZQ, Gu YJ, Huang GC. Immunohistochemical study on myoglobin in electrocution. J Forensic Med 13: 12-13,64 (1997) (PMID: 9644151) (in Chinese)
•Reviews:
1. Huang GC, Zhang JS. CCAAT/enhancer-binding protein family and liver diseases. Chin J Hepatol 11(1):57-59 (2003) (PMID: 12546754) (in Chinese)
•Meeting Abstracts:
1. Huang G, Brigstock DR. Differential modulation of integrins gene expression by connective tissue growth factor in early and activated primary culture hepatic stellate cells. Digestive Disease Week (DDW) 2009, May 30-June 4, Chicago, IL, USA. Meeting abstract published in Gastroenterology 136(Suppl):A-822 (2009)
2. Huang G, Brigstock DR. Integrin α5β1 is a CTGF receptor on early primary culture hepatic stellate cells and interacts with fibronectin and heparan sulfate proteglycans to regulate CTGF function. Digestive Disease Week (DDW) 2009, May 30-June 4, Chicago, IL, USA. Meeting abstract published in Gastroenterology 136(Suppl):A-823 (2009)
3. Huang GC*. Expression of c-maf gene in hepatic stellate cells. Digestive Disease Week (DDW) 2006, May 20-27, Los Angeles, CA, USA. Meeting abstract published in Gastroenterology 130(Suppl2):A796 (2006)
4. Huang GC, Tang QQ, Zhang JS. All-trans retinoic acid suppresses TGF-1-induced activation of rat hepatic stellate cells. The 95th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Feb 11-17, Atlanta, GA, USA. Meeting Abstract Published in Lab Invest 19(Suppl):273A (2006).
http://www.researcherid.com/rid/B-8399-2008
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