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Ge Zhang

City: Hong Kong

State/Province: Hong Kong

Country: China

Current Affiliation: Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China

Current Position: Research Assistant Professor

Field of Research: MEDICAL AND HEALTH SCIENCES - Other Medical and Health Sciences - Medical and Health Sciences not elsewhere classified

Professional Memberships: AO Foundation Reviewer,AO Research Review Commission

(www.aofoundation.org/aorf )

Lifetime Member of ICHT

Member of IBMS Committee Member of Chinese Osteoporosis Forum

(http://www.ichts.org/)

Member of International Bone and Mineral Society (http://www.ibmsonline.org/)

Editorial Member,Chinese Journal of Osteoporosis

Editorial Member, Chinese Osteoporosis Forum

Journal Reviewer, Bone

Journal Reviewer,Clinical Biomechanics

Journal Reviewer, Phytomedicine

Journal Reviewer, Phytotherapy Research

Journal Reviewer, Acta Pharmacologica Sinica

Notable Grants/Projects: 1.Therapeutic RNAi targeting CKIP-1 to reverse severe postmenopausal osteoporosis (Hong Kong Competitive Earmarked Research Grant)(CUHK479111)(HK$920,000.00)(Principal Investigator: Dr. Zhang Ge)

2.Blockade of VEGF-Src signaling as a novel therapeutic strategy to prevent destructive repair in steroid-associated osteonecrosis)(CUHK473011)(HK$862,500.00)(Principal Investigators: Dr. Qin Ling & Dr. Zhang Ge)

3.A Novel Selective–Estrogen-Receptor-Modulator Developed for Treatment of Osteoporosis in Cortical Bone of Ovariectomized Rat (Hong Kong Competitive Earmarked Research Grant)(CUHK 478508)（$HKD650000）（Principal Investigator: Dr. Zhang Ge）

4.Promoting osteoporotic fracture repair: Role of estrogen receptor beta pathway blockade (Switzerland AO Research Grant of the AO Foundation)(S0874Z)($HKD780000)）（Principal Investigator: Dr. Zhang Ge）

Research Interests: Research focus in Orthopedic Translational Research:
1. Musculoskeletal Biomechanics & Musculoskeletal Bio-imaging
2. Molecular mechanism of bone disorders (osteoporosis, osteoporotic fracture; osteonecrosis)
3. Screening of herb-derived small molecules for bone disorders
4. Stem-cell therapy for bone disorders
5. Small molecular drug, e.g. RNAi strategy, for skeletal disorders
6. Delivery system for RNAi strategy for skeletal disorders

Publication History: Zhang G (Corresponding Author), Guo BS, Wu H, Tang T, Zhang BT, et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine 2011 (In Print)

Zhu Hanmin (Co-first Author), Qin Ling (Co-first Author), Garnero P (Co-first Author), Genant HK (Co-first Author), Zhang Ge (Co-first Author), et al. The First Multicenter and Randomized Clinical Trial of Herbal Fufang for Treatment of Postmenopausal Osteoporosis. Osteoporosis Int 2011 (In print)

Zhang G (Corresponding Author), Tang T, Guo BS, et al. Therapeutic RNAi targeting CKIP-1 as a potential bone anabolic strategy. (Conditional Accept by Journal of Bone and Mineral Research)

Xie Xinhui , Wang Xinluan, He Yixin, Liu Zhong, Zhang Ge (Corresponding Author), Qin Ling (Corresponding Author). Implantation of cryopreserved bone marrow mononuclear cell to promote bone repair within steroid-associated osteonecrotic lesion in a rabbit model. Arthritis & Rheumatism 2011 (Accept)

Berry He, Zhang Ge (Corresponding Author), Liu Zhong, et al. Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model. Bone 2011; 48:1388-400

Zhang G, Sheng H, He YX, et al. Continuous occurrence of both insufficient neovascularization and elevated vascular permeability during inadequate repair of steroid-associated osteonecrotic lesions. Arthritis & Rheumatism 2009 ;60: 2966-77

Tang Tao(Co-first Author), Zhang G (Co-first Author), et al. Effect of water soluble P-chitosan and S-chitosan on human primary osteoblasts and giant cell tumour of bone stromal cells. Biomed Mater 2011 (In print)

Peng SL, Zhang G (Co-first Author), He YX, et al. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 2009; 45: 534-44

Zhang G, Wang XL, Sheng H, et al. Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets. PlosOne 2009; 4: e6419

Zhang G, Qin L, et al. A Novel Semisynthesized Small Molecule Icaritin Reduces Incidence of Steroid-associated Osteonecrosis with Inhibition of both Thrombosis and Lipid-deposition in a Dose-dependent Manner. Bone 2009; 44: 345-56

Zhang G, Qin L, Shi Y. Epimedium-Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24-Month Randomized, Double-Blind and Placebo-Controlled Trial. Journal of Bone and Mineral Research 2007; 22: 1072-1079

Zhang G, Qin L, Sheng H, et al. Epimedium-derived Phytoestrogen Exert Beneficial Effect on Preventing Steroid-associated Osteonecrosis in Rabbits with Inhibition of both Thrombosis and Lipid-Deposition. Bone 2007; 40: 685-692

Zhang G, Qin L, Hung WY, et al. Flavonoids Derived from Herbal Epimedium Brevicornum Maxim. Prevent OVX-induced Osteoporosis in Rats Independent of Its Enhancement in Intestinal Calcium Absorption. Bone 2006; 38: 818-825

Zhang G, Qin L, Shi YY, et al. Comparison between Axial Compression and Lateral Fall Configurations: A Rat Proximal femur Model. Clin Biomech 2005; 20: 729-735

Qin L, Zhang G, Sheng H, et al. Multiple imaging modalities in evaluation of experimental osteonecrosis induced by a combination of Lippolysaccharide and Methylprednisolone. Bone 2006; 39: 863-871

Hao YJ, Zhang G, Wang YS, Qin L, Hung WY, Leung KS, Pei FX. Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats. Bone 2007; 41:631-638

Sheng H, Zhang G, et al. Functional Perfusion MRI Predicts Later Occurrence of Steroid-Associated Osteonecrosis: An Experiment Study in Rabbits. Journal of Orthopedic Research 2009; 27: 742-7.

Qin L, Zhang G, Hung WY, et al. Phytoestrogen-rich Herb Formula ‘XLGB’ Prevents OVX-induced Deterioration of Musculoskeletal Tissues at Hip in Old Rats. J Bone Miner Metabol. 2005; 23: 55-61

Zhou XZ, Zhang G, Dong QR, Chan CW, Liu CF, Qin L. Low-dose X-irradiation promotes mineralization of fracture callus in a rat model. Arch Orthop Trauma Surg. 2009; 129: 125-132

Qin L, Zhang G, Sheng H, Wang XL, Wang YX, Yeung KW, JF. Griffith, Li ZR, Leung KS, Yao XS. Phytoestrogenic compounds for prevention of steroid-associated osteonecrosis. J Musculoskelet Neuronal Interact 2008; 8

Sheng H, Zhang G, Cheung WH, Chan CW, Wang YX, Lee KM, Wang HF, Leung KS, Qin LL. Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development. J Orthop Surg. 2007; 2:15.

Xie XH, Wang XL, Zhang G, et al. Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin. Biomed Mater. 2010 (In print)

Song XS, Zhou XZ, Zhang G, et al. Low-dose X-ray irradiation promotes fracture healing through up-regulation of vascular endothelial growth factor. Med Hypotheses. 2010;75:522-4

Zhang P, Qin L, Zhang G. The potential application of nicotinic acetylcholine receptor agonists for the treatment of rheumatoid arthritis. Inflamm Res. 2010; 59:415-7.

Xie XH, Wang XL, Zhang G, He YX, Wang XH, Liu Z, He K, Peng J, Leng Y, and Qin L. Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin. Biomed Mater 2010; 5(5): 054109.

Xie XH, Wang XL, Zhang G, Liu Z, Yao D, Hung LK, Hung VWY, and Qin L. Impaired bone healing in rabbits with steroid-associated osteonecrosis. J Bone Joint Surg Br 2010 (In print)